The voice actors/actress of Vampire Knight really suit the style of characters that the author is trying to convey in the manga. The person who does Zero is really versatile too...especially when much is demanded of Zero's character.
With the anime in actual fact, it is enhanced with the mystery of music whereas manga uses definitive shading and angles to convey the storyline and to depict the characters' moods effectively. There are pros and cons to using colour or just black and white.

MAJOR major Spoilers!!!! Do not reveal if you haven't seen the full anime series or that you have not read up to Chapter 51 of VK manga, you are warned~ As far as I am concerned, I am pretty sure that Chap 45 of VK manga is released before the last episode of Vampire Knight Guilty is made. However, the last 2 episodes of Guilty is actually made up by the producers/directors. Things that I will share are the final battle, love relationships, Kaien Cross, Bloody rose etc.